abstract：:Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck ca...

journal_title：Journal of dental research

authors： Victory K,Burd R,Fribley A,Sittadjody S,Arnett D,Klein RR,Limesand KH

更新日期：2011-03-01 00:00:00

abstract：:Catecholamines are present in saliva, but their influence on oral epithelium is not understood. Because psychological stress increases salivary catecholamines and impairs oral mucosal wound healing, we sought to determine if epithelial adrenergic signaling could link these two findings. We found that cultured human or...

journal_title：Journal of dental research

authors： Steenhuis P,Huntley RE,Gurenko Z,Yin L,Dale BA,Fazel N,Isseroff RR

更新日期：2011-02-01 00:00:00

abstract：:Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this s...

journal_title：Journal of dental research

authors： Xing Q,de Vos P,Faas MM,Ye Q,Ren Y

更新日期：2011-02-01 00:00:00

abstract：:Mastication as a mild but life-long exercise has been examined as a possibility for maintaining brain function in the elderly. Little is known, however, about the cerebral circulatory response during masticatory movement. The aim of this study was to develop a monitoring system for circulation dynamics during masticat...

journal_title：Journal of dental research

authors： Sakagami J,Ono T,Hasegawa Y,Hori K,Zhang M,Maeda Y

更新日期：2011-01-01 00:00:00

abstract：:Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a speci...

journal_title：Journal of dental research

authors： Li Q,Li X,Zhang F,Chen F

更新日期：2011-01-01 00:00:00

abstract：:Hemifacial microsomia (HFM) is a congenital disorder marked by facial asymmetry. Whether facial asymmetry accounts for asymmetrical dental development is unknown. There are few data on dental development relative to mandibular development or severity of HFM, or on development over time. We hypothesized that when mandi...

journal_title：Journal of dental research

authors： Ongkosuwito EM,de Gijt P,Wattel E,Carels CE,Kuijpers-Jagtman AM

更新日期：2010-12-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n ...

journal_title：Journal of dental research

authors： Hendler A,Mulli TK,Hughes FJ,Perrett D,Bombardieri M,Houri-Haddad Y,Weiss EI,Nissim A

更新日期：2010-12-01 00:00:00

abstract：:Dental caries is initiated by demineralization of the tooth surface through acid production by sugar metabolism of supragingival plaque microflora. To elucidate the sugar metabolic system, we used CE-MS to perform metabolomics of the central carbon metabolism, the EMP pathway, the pentose-phosphate pathway, and the TC...

journal_title：Journal of dental research

authors： Takahashi N,Washio J,Mayanagi G

更新日期：2010-12-01 00:00:00

abstract：UNLABELLED:We have previously shown that the resin monomer 2-hydroxyethylmethacrylate (HEMA) affects mouse B-lymphocyte activity, leading to increased IgG1 antibody production in vivo. In the present study, we tested, in vitro, the hypothesis that HEMA also affects human B-lymphocyte activity. The in vitro production o...

journal_title：Journal of dental research

authors： Andersson J,Dahlgren U

更新日期：2010-12-01 00:00:00

abstract：:Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets w...

journal_title：Journal of dental research

authors： Palmer CA,Kent R Jr,Loo CY,Hughes CV,Stutius E,Pradhan N,Dahlan M,Kanasi E,Arevalo Vasquez SS,Tanner AC

更新日期：2010-11-01 00:00:00

abstract：:Although a large body of scientific literature shows that background color and luminance affect color perception, previous measurements of tooth color difference thresholds have not taken the effects of viewing context into account. The present study tested the hypothesis that differences in skin/gingival color influe...

journal_title：Journal of dental research

authors： Lindsey DT,Wee AG

更新日期：2010-11-01 00:00:00

abstract：:Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...

journal_title：Journal of dental research

authors： Mangum JE,Crombie FA,Kilpatrick N,Manton DJ,Hubbard MJ

更新日期：2010-10-01 00:00:00

abstract：:Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcom...

journal_title：Journal of dental research

authors： Kebschull M,Demmer RT,Papapanou PN

更新日期：2010-09-01 00:00:00

abstract：:Bifidobacteria are aciduric bacteria that might play a role in the caries process. To test the hypothesis that Bifidobacteria behave as caries-associated organisms, as predicted by the ecological plaque hypothesis, we determined salivary levels of Bifidobacteria and caries-associated organisms for 156 older adults. Sa...

journal_title：Journal of dental research

authors： Beighton D,Al-Haboubi M,Mantzourani M,Gilbert SC,Clark D,Zoitopoulos L,Gallagher JE

更新日期：2010-09-01 00:00:00

abstract：:Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduc...

journal_title：Journal of dental research

authors： Su WW,Yen AM,Chiu SY,Chen TH

更新日期：2010-09-01 00:00:00

abstract：:Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types of human cells are not easily accessible to minimally invasive procedures. Here we evaluated dental pulp cells (DPCs) as an optimal source of iPS cells, since they are easily obtained ...

journal_title：Journal of dental research

authors： Tamaoki N,Takahashi K,Tanaka T,Ichisaka T,Aoki H,Takeda-Kawaguchi T,Iida K,Kunisada T,Shibata T,Yamanaka S,Tezuka K

更新日期：2010-08-01 00:00:00

abstract：:Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering. Here, we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional odontoblasts and endot...

journal_title：Journal of dental research

authors： Sakai VT,Zhang Z,Dong Z,Neiva KG,Machado MA,Shi S,Santos CF,Nör JE

更新日期：2010-08-01 00:00:00

abstract：:Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain pre...

journal_title：Journal of dental research

authors： Maloney WJ

更新日期：2010-07-01 00:00:00

abstract：:Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...

journal_title：Journal of dental research

authors： Chan HC,Mai L,Oikonomopoulou A,Chan HL,Richardson AS,Wang SK,Simmer JP,Hu JC

更新日期：2010-07-01 00:00:00

abstract：:Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective tissue. This study investigated the hypothesis that diabetes impairs connective tissue formation in healing gingiva, and that impaired healing is associated with ...

journal_title：Journal of dental research

authors： Desta T,Li J,Chino T,Graves DT

更新日期：2010-06-01 00:00:00

abstract：:Continuous etching of aggressive all-in-one adhesives occurs in wet dentin tubules after polymerization of the adhesives. This study challenged the hypothesis that unpolymerized acidic monomers from an aggressive all-in-one self-etching adhesive continue to etch beyond dentin hybrid layers. Dentin surfaces bonded with...

journal_title：Journal of dental research

authors： Kim J,Mai S,Carrilho MR,Yiu CK,Pashley DH,Tay FR

更新日期：2010-05-01 00:00:00

abstract：:Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time re...

journal_title：Journal of dental research

authors： Usui Y,Uematsu T,Uchihashi T,Takahashi M,Takahashi M,Ishizuka M,Doto R,Tanaka H,Komazaki Y,Osawa M,Yamada K,Yamaoka M,Furusawa K

更新日期：2010-05-01 00:00:00

abstract：:Current knowledge regarding the sensitivity of the teeth to forces is based on psychophysical experiments that measured touch detection thresholds under static jaw conditions. It is not known whether jaw movements alter the perception of forces applied to the teeth, but, based on limb movement studies, it is hypothesi...

journal_title：Journal of dental research

authors： Sowman PF,Brinkworth RS,Türker KS

更新日期：2010-04-01 00:00:00

abstract：:Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Hum...

journal_title：Journal of dental research

authors： Kim YK,Yiu CK,Kim JR,Gu L,Kim SK,Weller RN,Pashley DH,Tay FR

更新日期：2010-03-01 00:00:00

abstract：:Khat-chewing has been associated with oral lesions including oral cancer, but the mechanisms leading to their development are not known. We hypothesized that khat interferes with the physiological processes of the oral mucosa, such as cell proliferation and differentiation, and aimed at investigating the effects of kh...

journal_title：Journal of dental research

authors： Lukandu OM,Neppelberg E,Vintermyr OK,Johannessen AC,Costea DE

更新日期：2010-03-01 00:00:00

abstract：:Minimally invasive caries-removal procedures remove only caries-infected dentin and preserve caries-affected dentin that becomes remineralized. Dental cements containing calcium phosphate promote remineralization. This study evaluated the in vivo remineralization capacity of resin-based calcium-phosphate cement (Ca-P)...

journal_title：Journal of dental research

authors： Peters MC,Bresciani E,Barata TJ,Fagundes TC,Navarro RL,Navarro MF,Dickens SH

更新日期：2010-03-01 00:00:00

abstract：:Although pulp fibroblasts are a major cell type in dental pulp, their roles in microbial recognition and pulpal inflammation are not well-understood. Considering the pivotal role of Toll-like receptors (TLRs) in the recognition of micro-organisms, we hypothesized that TLRs on pulp fibroblasts may induce inflammatory s...

journal_title：Journal of dental research

authors： Park C,Lee SY,Kim HJ,Park K,Kim JS,Lee SJ

更新日期：2010-02-01 00:00:00

abstract：:Not only are teeth essential for mastication, but also missing teeth are considered a social handicap due to speech and aesthetic problems, with a resulting high impact on emotional well-being. Several treatment procedures are currently available for tooth replacement with mostly inert prosthetic materials and implant...

journal_title：Journal of dental research

authors： Fleischmannova J,Matalova E,Sharpe PT,Misek I,Radlanski RJ

更新日期：2010-02-01 00:00:00

abstract：:Stress-induced changes imparted in a 'dentin-bonded-crown' material during sintering, annealing, pre-cementation surface modification, and resin coating have been visualized by profilometry. The hypothesis tested was that operative techniques modify the stressing pattern throughout the material thickness. We polished ...

journal_title：Journal of dental research

authors： Isgró G,Addison O,Fleming GJ

更新日期：2010-01-01 00:00:00

abstract：:Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...

journal_title：Journal of dental research

authors： Hu WW,Ward BB,Wang Z,Krebsbach PH

更新日期：2010-01-01 00:00:00

abstract：:It has not been established whether transmission of mutans streptococci occurs between unrelated children older than 4 years of age. The aim of the study was to investigate the possible transmission of mutans streptococci genotypes from child to child in kindergarten. We studied 96 children (ages 5-6 yrs) in three San...

journal_title：Journal of dental research

authors： Doméjean S,Zhan L,DenBesten PK,Stamper J,Boyce WT,Featherstone JD

更新日期：2010-01-01 00:00:00

abstract：:Previously, in vitro differentiation of odontoblasts was shown for dental pulp stem cells (DPSCs) transfected with bone morphogenetic protein-2 (Bmp2). For this study, we hypothesized that such cells also show potential for mineralized tissue formation in vivo. DPSCs were transfected with Bmp2 and seeded onto a cerami...

journal_title：Journal of dental research

authors： Yang X,van der Kraan PM,Bian Z,Fan M,Walboomers XF,Jansen JA

更新日期：2009-11-01 00:00:00

abstract：:Mechanical removal of oral biofilms is ubiquitously accepted as the best way to prevent caries and periodontal diseases. Removal effectiveness strongly depends on biofilm strength. To investigate the influence of hydrodynamics on oral biofilm strength, we grew single- and multi-species biofilms of Streptococcus oralis...

journal_title：Journal of dental research

authors： Paramonova E,Kalmykowa OJ,van der Mei HC,Busscher HJ,Sharma PK

更新日期：2009-10-01 00:00:00

abstract：:Damage to the dentin matrix investigates the proliferation and mobilization of dental progenitor cells to the injury site, the mechanisms of which are not defined. EphB receptors and ephrin-B ligands expressed within the perivascular niche of dental pulp have been implicated following tooth injury. We propose that ele...

journal_title：Journal of dental research

authors： Arthur A,Koblar S,Shi S,Gronthos S

更新日期：2009-09-01 00:00:00

abstract：:Rotational freedom of the implant-abutment connection influences its screw joint stability; for optimization, influential factors need to be evaluated based on a previously developed closed formula. The underlying hypothesis is that the manufacturing tolerances, geometric pattern, and dimensions of the index do not in...

journal_title：Journal of dental research

authors： Semper W,Kraft S,Krüger T,Nelson K

更新日期：2009-08-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in periodontal tissue destruction. Our aim was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on: (i) the production of various MMPs by human monocyte-derived ma...

journal_title：Journal of dental research

authors： La VD,Howell AB,Grenier D

更新日期：2009-07-01 00:00:00

abstract：:Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in...

journal_title：Journal of dental research

authors： Ohyama H,Kato-Kogoe N,Kuhara A,Nishimura F,Nakasho K,Yamanegi K,Yamada N,Hata M,Yamane J,Terada N

更新日期：2009-07-01 00:00:00

abstract：:Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient in Polaris, a critical primary cilium component, in cartilage. Mutant post-natal cranial bases were deformed, and their synchondrosis g...

journal_title：Journal of dental research

authors： Ochiai T,Nagayama M,Nakamura T,Morrison T,Pilchak D,Kondo N,Hasegawa H,Song B,Serra R,Pacifici M,Koyama E

更新日期：2009-06-01 00:00:00

abstract：:Mutans streptococci (MS) are generally considered to be the principal etiological agent of dental caries. MS have two important virulence factors: cell- surface protein PAc and glucosyltransferases (GTFs). GTFs have two functional domains: an N-terminal catalytic sucrose-binding domain (CAT) and a C-terminal glucan-bi...

journal_title：Journal of dental research

authors： Niu Y,Sun J,Fan M,Xu QA,Guo J,Jia R,Li Y

更新日期：2009-05-01 00:00:00

abstract：:Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-...

journal_title：Journal of dental research

authors： Hatakeyama J,Fukumoto S,Nakamura T,Haruyama N,Suzuki S,Hatakeyama Y,Shum L,Gibson CW,Yamada Y,Kulkarni AB

更新日期：2009-04-01 00:00:00